Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration
نویسندگان
چکیده
منابع مشابه
Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration
Axolotls are uniquely able to mobilize neural stem cells to regenerate all missing regions of the spinal cord. How a neural stem cell under homeostasis converts after injury to a highly regenerative cell remains unknown. Here, we show that during regeneration, axolotl neural stem cells repress neurogenic genes and reactivate a transcriptional program similar to embryonic neuroepithelial cells. ...
متن کامل19-P040 Molecular analysis of spinal cord regeneration in Axolotl
sue is known as transdifferentiation, in which the local cells are able to dedifferentiate (lose the characteristics of their origin) and subsequently redifferentiate. Our lab has shown by transient lineage tracing that spinal cord cells (radial glial cells) can migrate into surrounding tissues and contribute to non-neural cells during regeneration [Science 298 (2002) 1993–1996]. In order to fo...
متن کاملO27: The Role of Hydrogels and Cell Based Therapies in Regeneration of Spinal Cord Injury
Spinal cord injury (SCI) is one of the devastating conditions leading to functional and neurological deficits following road traffic accidents. To date, there is no definite treatment for repairing damaged spinal cord tissue. In this regard, cell therapy opens a new window in front of scientists by using different cells such as mesenchymal stem cells, olfactory ensheathing cells, Schwann cells,...
متن کاملPhysiological Genomics of Spinal Cord and Limb Regeneration in a Salamander, the Mexican Axolotl
OF DISSERTATION James Robert Monaghan The Graduate School University of Kentucky 2009
متن کاملA clonal analysis of neural progenitors during axolotl spinal cord regeneration reveals evidence for both spatially restricted and multipotent progenitors.
Complete regeneration of the spinal cord occurs after tail regeneration in urodele amphibians such as the axolotl. Little is known about how neural progenitor cells are recruited from the mature tail, how they populate the regenerating spinal cord, and whether the neural progenitor cells are multipotent. To address these issues we used three types of cell fate mapping. By grafting green fluores...
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ژورنال
عنوان ژورنال: eLife
سال: 2021
ISSN: 2050-084X
DOI: 10.7554/elife.55665